Listing a study does not mean it has been evaluated by the U.S. Federal Government. Immunotherapy for the treatment of multiple myeloma. Navigating Individual Treatment for Relapsed/Refractory Multiple Myeloma. Dr. Saad Usmani is joined by Dr. Sham Mailankody to discuss cellular therapy in Relapsed/Refractory Multiple Myeloma. Dec 21 2021 Relapsed/Refractory Multiple Myeloma: Bispecifics - YouTube Janssen Announces U.S. FDA Breakthrough Therapy ... Isatuximab plus pomalidomide and low-dose dexamethasone ... March 12, 2021. Multiple myeloma (MM) is a hematological malignancy that remains incurable because most patients eventually relapse or become refractory to current treatments. Relapsed vs. Refractory Multiple Myeloma - Verywell Health Multiple myeloma: Regimens used for relapsed or refractory ... The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Novel immunomodulators, proteasome inhibitors, monoclonal antibodies, histone deacetylase inhibitors, and nuclear export inhibitors have all been added to the armamentarium, and the choice of which of these drugs or drug combinations to use depends on . DIAGNOSTIC APPROACH IN RELAPSE AND REFRACTORY MULTIPLE MYELOMA Several diagnostic procedures should be undertaken for patients with RRMM, including serum and urine protein electrophoresis and immunofixation, urine total protein, serum-free light chain, serum beta-2-microglobulin, and serum lactate dehydrogenase (LDH) tests. Multiple myeloma is a cancer that affects a type of white blood cell called a plasma cell, which helps your immune system fight infections. Participants with relapsed/refractory multiple myeloma who have had 3 or more prior therapies including an IMiD and a PI will receive magrolimab as per protocol and bortezomib 1.3 mg/m^2 on Days 8, 15, 22, 29 of Cycle 1, Days 1, 8, 15, 22 of Cycle 2 and onward (Maximum of 8 cycles in those who have previously received bortezomib) and dexamethasone 40 mg on Days 1, 8, 15, 22, 29 of Cycle 1 . 1: Breakthroughs in Therapeutic Options for Relapsed/Refractory Multiple Myeloma. The percent of myeloma deaths is highest among people aged 75-84. Tests carried out include:   Nina Shah, MD, discusses how to properly navigate treatment plans for patients with relapsed/refractory multiple myeloma. Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma Ide-cel induced responses in a majority of heavily pretreated patients with refractory and relapsed myeloma; MRD-negative status was achieved in 26% of treated patients. Epub 2013 . If it doesn't respond to treatment or comes. In addition, some patients will not respond to initial treatment (ie, refractory disease). 2013;121(11):1968-1975. 66. March 11, 2021. Myeloma is the fifteenth leading cause of cancer death in the United States. Cancer 124 (20): 4032-4043, 2018. Blood Adv. Triple-class refractory Introduction Multiple myeloma (MM), characterized by the expansion of malignant plasma cells in the bone marrow, 1 accounts for ∼1% of all malignancies and 10% of hematologic malignancies. The cause of multiple myeloma is unknown. In this video, Sham Mailankody highlights PFS findings in cell-to-cell therapy and his own GPRC5D study, looking at a new target for CAR T-cell therapy in myeloma. Survival rates for myeloma are generally based on if a single plasmacytoma is found or if multiple myeloma is diagnosed. Jung SH, et al. Patients with so-called triple-class refractory multiple myeloma have poor survival, substantial hospitalizations, and a clinically meaningful decline in health-related quality of life, according . 41,42 For a specific subgroup of patients, the efficacy of the anti-Bcl-2 inhibitor venetoclax in patients with t . Nina Shah, MD. CARTITUDE-1 (NCT03548207) is an ongoing Phase 1b/2, open-label, multi-center study evaluating the safety and efficacy of cilta-cel in adults with relapsed and/or refractory multiple myeloma, including 99 percent who were refractory to the last line of treatment and 88 percent of who were triple-class refractory, meaning their cancer did not . Clonal evolution of MM cells and bone marrow microenvironment changes contribute to drug resistance. Dimopoulos MA, Lonial S, Betts KA, et al. In heavily pretreated relapsed/refractory multiple myeloma cell lines with t (11;14), selinexor (Xpovio) combined with venetoclax (Venclexta) demonstrated efficacy and tolerability, according to small study results that were presented during the 2021 ASH Annual Meeting. In Multiple Myeloma Today's roundtable series discussing research presented at ASH 2021, moderator Dr. Saad Usmani is joined by Dr. Sham Mailankody to discus. In this situation, Darzalex is used with the medications pomalidomide (Pomalyst) and dexamethasone. Antengene Receives Approval In China For XPOVIO For Treatment Of Refractory Multiple Myeloma . Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: identification of prognostic factors in a phase 2 study of 169 patients. The diagnosis of relapsed or refractory multiple myeloma depends on bone marrow tests and markers that can be detected in blood and sometimes in urine, all in addition to any signs and symptoms that may be present. Idecabtagene vicleucel (ide-cel), a B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T cell therapy, showed deep, durable responses in patients with triple-class exposed (TCE) relapsed and refractory multiple myeloma (RRMM) in the phase 2 KarMMa trial. Dec. 17, 2021, 08:44 AM Uncovering novel targets for therapeutic intervention is imperative for the treatment of patients that have depleted all currently available treatment options. Relapsed/Refractory Multiple Myeloma Landscape Relapsed/Refractory Multiple Myeloma Landscape November 12, 2021 Kenneth H. Shain, MD, PhD Kenneth Shain, MD, PhD provides an overview of recent. Patients with triple-class refractory multiple myeloma (TCR MM) experienced poor survival, significant hospitalizations, and a clinically meaningful decline in health-related quality of life (HRQoL), according to data from the Connect MM Disease Registry presented at the American Society of Hematology's 2021 Annual Meeting and Exposition. In adults who have received two or more previous multiple myeloma treatments that included lenalidomide and a proteasome inhibitor, which is a type of drug. Critical Reviews in Oncology/Hematology. A Study in Subjects With Relapsed/Refractory Multiple Myeloma and Relapsed/Refractory Diffuse Large B-Cell Lymphoma. After each relapse, treatment regimens result in progressively lower response rates, shorter response durations, and increasing drug resistance, thereby diminishing the number of treatment options. Refractory Myeloma Dr. Damian Green, MD of the Fred Hutchinson Cancer Center, generally defines Refractory Myeloma as "disease that is progressing despite active treatment." The National Cancer Institute breaks it down even further to say that there are two main types of refractory myeloma patients: 1. Despite the availability of new treatments, most patients with multiple myeloma will become refractory to the therapies that currently comprise the hematologic standard of care for the malignancy, including proteasome inhibitors, immunomodulatory agents, and . Dr. Saad Usmani is joined by Dr. Sham Mailankody to discuss cellular therapy in Relapsed/Refractory Multiple Myeloma. With so many recent advances in relapsed/refractory multiple myeloma, keeping abreast with current treatment recommendations can be challenging. Venetoclax is a selective, orally bioavailable BCL-2 inhibitor that induces cell death in multiple myeloma (MM) cells, particularly in those harboring t(11;14), which express high levels of BCL-2 relative to BCL-X L and MCL-1. Leukemia. Multiple myeloma is clinically and pathologically heterogeneous, which results in variability in treatment response and survival. Isatuximab plus carfilzomib and dexamethasone vs carfilzomib and dexamethasone in relapsed/refractory multiple myeloma (IKEMA): interim analysis of a phase 3, randomized, open-label study. In 2020, the European Commission and the U.S. Food and Drug Administration each granted teclistamab orphan drug . RTTNews . Online ahead of print. Cilta-Cel Produces 'Durable and Deep' Responses in Relapsed/Refractory Multiple Myeloma Andrea S. Blevins Primeau, PhD, MBA The stringent complete response rate increased from 67% at 1 year to 83%. 1,3,4 Furthermore, patients with relapsed and refractory multiple myeloma (RRMM) may have comorbidities . : Elotuzumab plus lenalidomide and dexamethasone in relapsed/refractory multiple myeloma: Extended 4-year follow-up and analysis of relative progression-free survival from the randomized ELOQUENT-2 trial. December 22, 2021. 3 , 4 Moreau P, Dimopoulos MA, Mikhael J, et al. For Immediate Release: July 03, 2019. 2019. The CAR T-cell therapy ciltacabtagene autoleucel (cilta-cel; JNJ-68284528) led to a high response rate and an acceptable safety profile at the recommended phase 2 dose in patients with relapsed or refractory multiple myeloma, according to findings from the CARTITUDE-1 trial (NCT03548207) that were presented during the 2020 ASH Annual Meeting. 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